Non smc condensin i complex software

We therefore evaluated the prognostic value and biological function of ncapd2 in tnbc. Brrn1 antibody nonsmc condensin i complex, subunit h. Contribution of hcapd2, a nonsmc subunit of condensin i. However, the mechanisms through which ncaph affects pancreatic cancer pc and its molecular function remain unclear. Required for decatenation of noncentromeric ultrafine dna bridges during anaphase. Nonsmc condensin i complex subunit d2 ncapd2 and nonsmc. Ipr025977 nuclear condensin complex subunit 3, cterminal domain. Brrn1 antibody nonsmc condensin i complex, subunit h, 25. Caph2, proteins that are distantly related to the non smc subunits of the originally identified complex, now called condensin i. Nonsmc condensin i complex proteins control chromosome. Previously we performed comprehensive gene expression analysis on primary and recurrent oscc by using cdna microarray. The nonsmc subunits of the condensin complexes have been proposed to activate dna supercoiling and looping activity of the smcatpases and to play essential roles in directing the association of the condensin holocomplex onto chromosomes at the correct mitotic stage 4, 6. Nonsmc condensin i complex subunit d2 is a prognostic.

Nonsmc condensin i complex subunit h ncaph is associated with lymphangiogenesis and drug resistance in oral squamous cell carcinoma. Nonsmc condensin i complex subunit h ncaph is a vital gene associated with chromosome stability and is required for proper chromosome condensation and segregation. The role of nonsmc condensin i complex subunit d2 ncapd2, a regulatory subunit of the condensin i complex that mainly participates in chromosome condensation and segregation, has not been reported in cancer. In this study, we examined the role of ncaph in pc cells. Overexpression of nonsmc condensin i complex subunit g serves. Distinct functions of condensin i and ii in mitotic. Additionally, condensin i complexes feature nonsmc condensin i complex subunits h ncaph, g ncapg, and d2 ncapd2 6,7. Smc condensin i complex subunit h ncaph encodes a regulatory. Here, we used an rna interference approach to deplete hcapd2, a nonsmc subunit of condensin i, in hela cells. Overexpression of ncaph is upregulated and predicts a poor. The nonsmc condensin i complex subunit g ncapg that. Ks is supported by biomedical research program funds at weill cornell. Jcm free fulltext nonsmc condensin i complex subunit h. Each of the complexes contains a distinct set of nonsmc regulatory subunits a kleisin subunit and a pair of heatrepeat subunits.

Nonsmc condensin i complex subunit h mediates mature. Nonsmc condensin i complex proteins control chromosome segregation and survival of proliferating cells in the zebrafish neural retina. Recent studies highlighted the nonsmc condensin i complex. Systems biology analysis merging phenotype, metabolomic and. Nonsmc condensin i complex subunit h ncaph is a vital gene. Ncapd2 condensin complex subunit 1 mus musculus mouse. Annotation program, chordata protein annotation program. Condensin i and ii are enriched at different sites along chromatid axes, and their depletion causes different morphological.

However, the relationship between ncaph and hepatocellular carcinoma hcc remains unclear. Condensin complex subunit 2 also known as chromosomeassociated protein h caph or nonsmc condensin i complex. The nematode caenorhabditis elegans possesses a third complex closely related to condensin i that participates in chromosomewide gene regulation, i. The condensin i subunit barrencaph is essential for the.

In addition to smc2 and smc4, condensin ii contains capd3hhcp6, capg2 and kleisin. The upregulation of ncaph is associated with poor prognosis in patients with colon cancer. Ncapg condensin complex subunit 3 homo sapiens human. Smc condensing i complex subunit h ncaph is a member of the barr protein family and part of the condensin i complex.